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1

T-Cell–Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028

Ott, Patrick A., Bang, Yung-Jue, Piha-Paul, Sarina A., Razak, Albiruni R. Abdul, Bennouna, Jaafar, Soria, Jean-Charles, Rugo, Hope S., Cohen, Roger B., O’Neil, Bert H., Mehnert, Janice M., Lopez, Juan

Journal:

Journal of Clinical Oncology

Year:

2019

Language:

english

File:

PDF, 1.12 MB

english, 2019

2

[Cancer Treatment and Research] Melanoma Volume 167 || Melanoma Epidemiology and Prevention

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 340 KB

english, 2016

3

Safety and Antitumor Activity of Pembrolizumab in Advanced Programmed Death Ligand 1–Positive Endometrial Cancer

Ott, Patrick A., Bang, Yung-Jue, Berton-Rigaud, Dominique, Elez, Elena, Pishvaian, Michael J., Rugo, Hope S., Puzanov, Igor, Mehnert, Janice M., Aung, Kyaw L., Lopez, Juanita, Carrigan, Marion, Saraf,

Journal:

Obstetric and Gynecologic Survey

Year:

2018

Language:

english

File:

PDF, 78 KB

english, 2018

4

Biomarkers for Response to Immune Checkpoint Blockade

Ganesan, Shridar, Mehnert, Janice

Journal:

Annual Review of Cancer Biology

Year:

2020

File:

PDF, 3.37 MB

2020

5

Pembrolizumab for the treatment of programmed deathâligand 1âpositive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTEâ028 study

Mehnert, Janice M., Bergsland, Emily, OâNeil, Bert H., Santoro, Armando, Schellens, Jan H. M., Cohen, Roger B., Doi, Toshihiko, Ott, Patrick A., Pishvaian, Michael J., Puzanov, Igor, Aung, Kyaw L.,

Journal:

Year:

2020

File:

PDF, 649 KB

2020

6

Phase I study of gemcitabine, docetaxel and imatinib in refractory and relapsed solid tumors

Biren Saraiya, Rashmi Chugh, Vassiliki Karantza, Janice Mehnert, Rebecca A. Moss, Nelli Savkina, Mark N. Stein, Laurence H. Baker, Thomas Chenevert, Elizabeth A. Poplin

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 499 KB

english, 2012

7

Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays

Janice M. Mehnert, Mary M. McCarthy, Lucia Jilaveanu, Keith T. Flaherty, Saadia Aziz, Robert L. Camp, David L. Rimm, Harriet M. Kluger

Journal:

Human Pathology

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

8

Vasoactive intestinal peptide regulation of nerve growth factor in the embryonic mouse

Joanna M Hill, Janice Mehnert, Susan K McCune, Douglas E Brenneman

Journal:

Year:

2002

Language:

english

File:

PDF, 168 KB

english, 2002

9

Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies

Janice M. Mehnert, Harriet M. Kluger

Journal:

Current Oncology Reports

Year:

2012

Language:

english

File:

PDF, 179 KB

english, 2012

10

When Benign Tumors Mimic Malignancies: A Case of Lymphangiomatosis Masquerading as Metastatic Disease

Spencer, Kristen R., Miettinen, Markku M., Maki, Robert G., Mehnert, Janice M.

Journal:

Rare Cancers and Therapy

Year:

2013

Language:

english

File:

PDF, 623 KB

english, 2013

11

Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor

Teh, Jessica L. F., Shah, Raj, Shin, Seung-Shick, Wen, Yu, Mehnert, Janice M., Goydos, James, Chen, Suzie

Journal:

Pigment Cell & Melanoma Research

Year:

2014

Language:

english

File:

PDF, 7.77 MB

english, 2014

12

Ipilimumab administration for advanced melanoma in patients with pre-existing Hepatitis B or C infection: a multicenter, retrospective case series

Ravi, Sowmya, Spencer, Kristen, Ruisi, Mary, Ibrahim, Nageatte, Luke, Jason J, Thompson, John A, Shirai, Keisuke, Lawson, David, Bartell, Heddy, Kudchadkar, Ragini, Gunter, Ngoc, Mehnert, Janice M, Li

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2014

Language:

english

File:

PDF, 428 KB

english, 2014

13

Oncolytic Virus Immunotherapy for Melanoma

Dharmadhikari, Neal, Mehnert, Janice M., Kaufman, Howard L.

Journal:

Current Treatment Options in Oncology

Year:

2015

Language:

english

File:

PDF, 860 KB

english, 2015

14

Clinical Management of Multiple Melanoma Brain Metastases

Goyal, Sharad, Silk, Ann W., Tian, Sibo, Mehnert, Janice, Danish, Shabbar, Ranjan, Sinthu, Kaufman, Howard L.

Journal:

Year:

2015

Language:

english

File:

PDF, 117 KB

english, 2015

15

A Phase II Study of AT-101 to Overcome Bcl-2 Mediated Resistance to Androgen Deprivation Therapy in Patients with Newly Diagnosed Castration Sensitive Metastatic Prostate Cancer

Stein, Mark N., Hussain, Maha, Stadler, Walter M., Liu, Glenn, Tereshchenko, Irina V., Goodin, Susan, Jeyamohan, Chandrika, Kaufman, Howard L., Mehnert, Janice, DiPaola, Robert S.

Journal:

Clinical Genitourinary Cancer

Year:

2015

Language:

english

File:

PDF, 902 KB

english, 2015

16

[Cancer Treatment and Research] Melanoma Volume 167 ||

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 6.95 MB

english, 2016

17

[Cancer Treatment and Research] Melanoma Volume 167 || Novel Treatments in Development for Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 645 KB

english, 2016

18

[Cancer Treatment and Research] Melanoma Volume 167 || Methods of Melanoma Detection

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 1.26 MB

english, 2016

19

[Cancer Treatment and Research] Melanoma Volume 167 || Principles of Melanoma Staging

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 433 KB

english, 2016

20

[Cancer Treatment and Research] Melanoma Volume 167 || Targeted Therapy for Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 175 KB

english, 2016

21

[Cancer Treatment and Research] Melanoma Volume 167 || Treatment of Uveal Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 162 KB

english, 2016

22

[Cancer Treatment and Research] Melanoma Volume 167 || Mucosal Melanoma: Epidemiology, Biology and Treatment

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 428 KB

english, 2016

23

[Cancer Treatment and Research] Melanoma Volume 167 || Heterogeneity in Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 684 KB

english, 2016

24

[Cancer Treatment and Research] Melanoma Volume 167 || Acral Lentiginous Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 334 KB

english, 2016

25

[Cancer Treatment and Research] Melanoma Volume 167 || Checkpoint Blockade for the Treatment of Advanced Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 191 KB

english, 2016

26

[Cancer Treatment and Research] Melanoma Volume 167 || Chemotherapy for Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 204 KB

english, 2016

27

[Cancer Treatment and Research] Melanoma Volume 167 || Adjuvant Therapy of Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 227 KB

english, 2016

28

[Cancer Treatment and Research] Melanoma Volume 167 || Pediatric Melanoma and Atypical Melanocytic Neoplasms

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 527 KB

english, 2016

29

[Cancer Treatment and Research] Melanoma Volume 167 || Melanoma: Clinical Presentations

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 435 KB

english, 2016

30

[Cancer Treatment and Research] Melanoma Volume 167 || Treatment of Melanoma CNS Metastases

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 185 KB

english, 2016

31

[Cancer Treatment and Research] Melanoma Volume 167 || Surgical Management of Melanoma

Kaufman, Howard L., Mehnert, Janice M.

Year:

2016

Language:

english

File:

PDF, 557 KB

english, 2016

32

Importance of including patients with comorbidities in clinical trials

Spencer, Kristen R, Mehnert, Janice M

Journal:

The Lancet Oncology

Year:

2016

Language:

english

File:

PDF, 99 KB

english, 2016

33

Histone Deacetylase Inhibitors: Biology and Mechanism of Action

Mehnert, Janice M., Kelly, Wm Kevin

Journal:

The Cancer Journal

Year:

2007

Language:

english

File:

PDF, 294 KB

english, 2007

34

OA05.01 Pembrolizumab in Patients with Extensive-Stage Small Cell Lung Cancer: Updated Survival Results from KEYNOTE-028

Ott, Patrick, Felip, Enriqueta, Hiret, Sandrine, Kim, Dong-Wan, Morosky, Anne, Saraf, Sanatan, Piperdi, Bilal, Mehnert, Janice

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 96 KB

english, 2017

35

A phase I dose-escalation study of the safety and pharmacokinetics of a tablet formulation of voxtalisib, a phosphoinositide 3-kinase inhibitor, in patients with solid tumors

Mehnert, Janice M., Edelman, Gerald, Stein, Mark, Camisa, Heather, Lager, Joanne, Dedieu, Jean-François, Ghuysen, Anne-Frédérique, Sharma, Jyoti, Liu, Li, LoRusso, Patricia M.

Journal:

Investigational New Drugs

Year:

2017

Language:

english

File:

PDF, 491 KB

english, 2017

36

The Challenge for Development of Valuable Immuno-oncology Biomarkers

Mehnert, Janice M., Monjazeb, Arta M., Beerthuijzen, Johanna M.T., Collyar, Deborah, Rubinstein, Larry, Harris, Lyndsay N.

Journal:

Clinical Cancer Research

Year:

2017

Language:

english

File:

PDF, 1.02 MB

english, 2017

37

Immuno-oncology Clinical Trial Design: Limitations, Challenges, and Opportunities

Baik, Christina S., Rubin, Eric H., Forde, Patrick M., Mehnert, Janice M., Collyar, Deborah, Butler, Marcus O., Dixon, Erica L., Chow, Laura Q.M.

Journal:

Clinical Cancer Research

Year:

2017

Language:

english

File:

PDF, 610 KB

english, 2017

38

Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer

Panda, Anshuman, Mehnert, Janice M, Hirshfield, Kim M, Riedlinger, Greg, Damare, Sherri, Saunders, Tracie, Kane, Michael, Sokol, Levi, Stein, Mark N, Poplin, Elizabeth, Rodriguez-Rodriguez, Lorna, Sil

Journal:

JNCI Journal of the National Cancer Institute

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

39

A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma

Mehnert, Janice M., Silk, Ann W., Wen, Yu, Lee, J. H., Dudek, Liesel, Jeong, Byeong-Seon, Li, Jiadong, Schenkel, Jason M., Sadimin, Evita, Kane, Michael, Lin, Hongxia, Shih, Weichung J., Zloza, Andrew

Journal:

Pigment Cell & Melanoma Research

Year:

2018

Language:

english

File:

PDF, 906 KB

english, 2018

40

Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials

Kelly, Karen, Infante, Jeffrey R., Taylor, Matthew H., Patel, Manish R., Wong, Deborah J., Iannotti, Nicholas, Mehnert, Janice M., Loos, Anja H., Koch, Helga, Speit, Isabell, Gulley, James L.

Journal:

Year:

2018

Language:

english

File:

PDF, 311 KB

english, 2018

41

Efficacy and safety of high-dose interleukin-2 treatment in patients with a history of brain metastases from renal cell carcinoma

Chandar, Ashwin, Silk, Ann W, Clark, Joseph I, Daniels, Gregory A, McDermott, David F, Morse, Michael, Wong, Michael KK, Stein, Mark, Mehnert, Janice, Danish, Shabbar, Aung, Sandra, Kaufman, Howard L

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2015

Language:

english

File:

PDF, 210 KB

english, 2015

42

Phase Ib Results of the Rational Combination of Selumetinib and Cyclosporin A in Advanced Solid Tumors with an Expansion Cohort in Metastatic Colorectal Cancer

Krishnamurthy, Anuradha, Dasari, Arvind, Noonan, Anne M., Mehnert, Janice M., Lockhart, Albert Craig, Leong, Stephen, Capasso, Anna, Stein, Mark N, Sanoff, Hanna K., Lee, James J, Hansen, Aaron, Malho

Journal:

Cancer Research

Year:

2018

Language:

english

File:

PDF, 1018 KB

english, 2018

43

Multicenter Phase 2 Trial of Gemcitabine, Carboplatin, and Sorafenib in Patients With Metastatic or Unresectable Transitional-Cell Carcinoma

Hurwitz, Michael E., Markowski, Paul, Yao, Xiaopan, Deshpande, Hari, Patel, Jaymin, Mortazavi, Amir, Donadio, Alessia, Stein, Mark N., Kelly, William Kevin, Petrylak, Daniel Peter, Mehnert, Janice M.

Journal:

Clinical Genitourinary Cancer

Year:

2018

Language:

english

File:

PDF, 637 KB

english, 2018

44

Pembrolizumab in patients with programmed death ligand 1–positive advanced ovarian cancer: Analysis of KEYNOTE-028

Varga, Andrea, Piha-Paul, Sarina, Ott, Patrick A., Mehnert, Janice M., Berton-Rigaud, Dominique, Morosky, Anne, Yang, Ping, Ruman, Jane, Matei, Daniela

Journal:

Gynecologic Oncology

Year:

2018

Language:

english

File:

PDF, 541 KB

english, 2018

45

Treatment of Recurrent Metastatic Head and Neck Cancer: Focus on Cetuximab

Patel, Akshar N., Mehnert, Janice M., Kim, Sung

Journal:

Clinical Medicine Insights Ear Nose and Throat

Year:

2012

Language:

english

File:

PDF, 521 KB

english, 2012

46

Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma

D’Angelo, Sandra P., Hunger, Matthias, Brohl, Andrew S., Nghiem, Paul, Bhatia, Shailender, Hamid, Omid, Mehnert, Janice M., Terheyden, Patrick, Shih, Kent C., Brownell, Isaac, Lebbé, Céleste, Lewis, K

Journal:

Cancer Immunology, Immunotherapy

Year:

2019

Language:

english

File:

PDF, 802 KB

english, 2019

47

Pembrolizumab in Patients With Extensive-Stage Small-Cell Lung Cancer: Results From the Phase Ib KEYNOTE-028 Study

Ott, Patrick A., Elez, Elena, Hiret, Sandrine, Kim, Dong-Wan, Morosky, Anne, Saraf, Sanatan, Piperdi, Bilal, Mehnert, Janice M.

Journal:

Journal of Clinical Oncology

Year:

2017

File:

PDF, 942 KB

2017

48

Safety and Antitumor Activity of Pembrolizumab in Advanced Programmed Death Ligand 1–Positive Endometrial Cancer: Results From the KEYNOTE-028 Study

Ott, Patrick A., Bang, Yung-Jue, Berton-Rigaud, Dominique, Elez, Elena, Pishvaian, Michael J., Rugo, Hope S., Puzanov, Igor, Mehnert, Janice M., Aung, Kyaw L., Lopez, Juanita, Carrigan, Marion, Saraf,

Journal:

Journal of Clinical Oncology

Year:

2017

Language:

english

File:

PDF, 682 KB

english, 2017

49

Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors

Panda, Anshuman, Betigeri, Anil, Subramanian, Kalyanasundaram, Ross, Jeffrey S., Pavlick, Dean C., Ali, Siraj, Markowski, Paul, Silk, Ann, Kaufman, Howard L., Lattime, Edmund, Mehnert, Janice M., Sull

Journal:

JCO Precision Oncology

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

50

Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors

Panda, Anshuman, Betigeri, Anil, Subramanian, Kalyanasundaram, Ross, Jeffrey S., Pavlick, Dean C., Ali, Siraj, Markowski, Paul, Silk, Ann, Kaufman, Howard L., Lattime, Edmund, Mehnert, Janice M., Sull

Journal:

JCO Precision Oncology

Year:

2017

File:

PDF, 1.14 MB

2017